Herpesvirus Envelopment
نویسندگان
چکیده
منابع مشابه
The Two Envelopes Problem: Recent Developments in Identifying the Second Membrane in Herpesvirus Envelopment
Virion assembly represents an elaborate molecular jigsaw, coordinating numerous individual components to construct an infectious agent. For enveloped viruses, such as HIV, influenza and Herpes Simplex Virus-1 (HSV1), a vital piece of this puzzle is the acquisition of a membrane. Unlike viral proteins, this is not produced de novo, but derived directly from existing host membranes. The host’s se...
متن کاملBovine herpesvirus 1 tegument protein UL21 plays critical roles in viral secondary envelopment and cell-to-cell spreading
Bovine herpesvirus 1 (BoHV-1) UL21 is a tegument protein thought to be indispensable for efficient viral growth but its precise function in BoHV-1 is currently unknown. To determine the function of UL21 in BoHV-1 replication, we constructed a mutant virus bearing a UL21 deletion (vBoHV-1-∆UL21) and its revertant virus, vBoHV-1-∆UL21R, in which the UL21 gene was restored using a bacterial artifi...
متن کاملThe alpha-TIF (VP16) homologue (ETIF) of equine herpesvirus 1 is essential for secondary envelopment and virus egress.
The equine herpesvirus 1 (EHV-1) alpha-trans-inducing factor homologue (ETIF; VP16-E) is a 60-kDa virion component encoded by gene 12 (ORF12) that transactivates the immediate-early gene promoter. Here we report on the function of EHV-1 ETIF in the context of viral infection. An ETIF-null mutant from EHV-1 strain RacL11 (vL11deltaETIF) was constructed and analyzed. After transfection of vL11del...
متن کاملEnvelopment Thomas Eisenmann Geoffrey
Due to network effects and switching costs, platform providers often become entrenched. To dislodge them, entrants generally must offer revolutionary products. We explore a second path to platform leadership change that does not rely on Schumpeterian creative destruction: platform envelopment. By leveraging common components and shared user relationships, one platform provider can move into ano...
متن کاملQuadratic Data Envelopment Analysis
Data Envelopment Analysis (DEA) provides means for piecewise linear approximation of production functions. To improve the fit to the data we propose to improve the flexibility of the frontier by extending DEA towards a more general piecewise quadratic approximation, called Quadratic Data Envelopment Analysis (QDEA). In contrast to the linear approximation, the quadratic approximation allows for...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Virology
سال: 1968
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.2.1.48-55.1968